Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

Advances in immunotherapy have led to durable and long‐term benefits in a subset of
patients across a number of solid tumor types. Understanding of the subsets of patients that …

Immune checkpoint inhibitors (ICI) targeting CTLA-4 and the PD-1/PD-L1 axis have shown
unprecedented clinical activity in several types of cancer and are rapidly transforming the …

Environmental nutrient availability influences T cell metabolism, impacting T cell function
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β …

T cells expressing chimeric antigen receptors (CAR T cells) have shown impressive
therapeutic efficacy against leukemias and lymphomas. However, they have not been as …

T cell activation is a highly regulated process involving peptide–MHC engagement of the T
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …

Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

Converting checkpoint inhibitor (CPI)-resistant individuals to being responsive requires
identifying suppressive mechanisms. We identify TREM2+ tumor-associated macrophages …

Summary Rewiring exhausted CD8+ T (Tex) cells toward functional states remains a
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …

Malignant transformation of cells depends on accumulation of DNA damage. Over the past
years we have learned that the T cell–based immune system frequently responds to the …