Early in the 1980s several laboratories mistakenly reported that partially purified interleukin-
1 (IL-1) was chemotactic for neutrophils. However, further investigations by us, revealed that …

Chemokines are small proteins that control several tissue functions, including cell
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …

Severe cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen
receptor T cell (CAR-T) therapy can be life-threatening in some cases, and management of …

The transforming growth factor beta (TGF‐β) family forms a group of three isoforms, TGF‐β1,
TGF‐β2, and TGF‐β3, with their structure formed by interrelated dimeric polypeptide chains …

Cytokines are bioactive proteins produced by many different cells of the immune system.
Due to their role in different inflammatory disease states and maintaining homeostasis, there …

Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

We have generated transgenic mouse lines carrying and expressing wild‐type and 3′‐
modified human tumour necrosis factor (hTNF‐alpha, cachectin) transgenes. We show that …

Tumor necrosis factor-α (TNF-α), a glial-cell-related factor, was measured for the first time in
the brain (striatum) and cerebrospinal fluid (CSF) from control and parkinsonian patients by …

Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving
immune responses impacted our understanding of periodontitis? J Clin Periodontol 2011; …