Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

A potentially important aspect in the regulation of tumour metastasis is endocytosis. This
process consists of internalisation of cell-surface receptors via pinocytosis, phagocytosis or …

Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

Exosomes are small vesicles that are secreted by cells and act as mediators of cell to cell
communication. Because of their potential therapeutic significance, important efforts are …

Cells maintain intracellular pH (pHi) within a narrow range (7.1–7.2) by controlling
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

This brief overview of endocytic trafficking is written in honor of Renate Fuchs, who retires
this year. In the mid-1980s, Renate pioneered studies on the ion-conducting properties of …

Integrins are a family of heterodimeric receptors that bind to components of the extracellular
matrix and influence cellular processes as varied as proliferation and migration. These …

Targeting of drugs and their carrier systems by using receptor-mediated endocytotic
pathways was in its nascent stages 25years ago. In the intervening years, an explosion of …

Carbon dioxide capture and storage (CCS) technology is considered by many to be an
essential route to meet climate mitigation targets in the power and industrial sectors …