The emerging roles of KPNA2 in cancer
Y Han, X Wang - Life sciences, 2020 - Elsevier
Abstract Karyopherin α2 (KPNA2, also known as importinα-1), a member of the nuclear
transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of …
transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of …
Nuclear pore complexes and nucleocytoplasmic transport: from structure to function to disease
A Dickmanns, RH Kehlenbach, B Fahrenkrog - International review of cell …, 2015 - Elsevier
Nucleocytoplasmic transport is an essential cellular activity and occurs via nuclear pore
complexes (NPCs) that reside in the double membrane of the nuclear envelope. Significant …
complexes (NPCs) that reside in the double membrane of the nuclear envelope. Significant …
[HTML][HTML] Comprehensive analysis of the competing endogenous circRNA-lncRNA-miRNA-mRNA network and identification of a novel potential biomarker for …
L Zhang, H Tao, J Li, E Zhang, H Liang… - Aging (Albany NY …, 2021 - ncbi.nlm.nih.gov
Background: The competing endogenous RNAs (ceRNAs) hypothesis has received
increasing attention as a novel explanation for tumorigenesis and cancer progression …
increasing attention as a novel explanation for tumorigenesis and cancer progression …
The interaction between S100A2 and KPNA2 mediates NFYA nuclear import and is a novel therapeutic target for colorectal cancer metastasis
F Han, L Zhang, S Liao, Y Zhang, L Qian, F Hou… - Oncogene, 2022 - nature.com
Nucleocytoplasmic transport of proteins is disrupted and dysregulated in cancer cells.
Nuclear pore complexes and cargo proteins are two main transportation regulators …
Nuclear pore complexes and cargo proteins are two main transportation regulators …
Karyopherin subunit-α 2 expression accelerates cell cycle progression by upregulating CCNB2 and CDK1 in hepatocellular carcinoma
CL Gao, GW Wang, GQ Yang, H Yang… - Oncology …, 2018 - spandidos-publications.com
Different types of cancer exhibit distinct gene expression profiles. The present study aimed
to identify a specific gene dysregulated in hepatocellular carcinoma (HCC) that was …
to identify a specific gene dysregulated in hepatocellular carcinoma (HCC) that was …
[HTML][HTML] MiR-26b/KPNA2 axis inhibits epithelial ovarian carcinoma proliferation and metastasis through downregulating OCT4
J Lin, L Zhang, H Huang, Y Huang, L Huang, J Wang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Karyopherin alpha 2 (KPNA2) is a nuclear transport protein upregulated in many
cancers. Our previous study has identified KPNA2 overexpression in epithelial ovarian …
cancers. Our previous study has identified KPNA2 overexpression in epithelial ovarian …
Identification of the differential expression of genes and upstream microRNAs in small cell lung cancer compared with normal lung based on bioinformatics analysis
X Li, C Ma, H Luo, J Zhang, J Wang, H Guo - Medicine, 2020 - journals.lww.com
Small cell lung cancer (SCLC) is one of the most lethal cancer, mainly attributing to its high
tendency to metastasis. Mounting evidence has demonstrated that genes and microRNAs …
tendency to metastasis. Mounting evidence has demonstrated that genes and microRNAs …
Diagnostic significance and carcinogenic mechanism of pan‐cancer gene POU5F1 in liver hepatocellular carcinoma
D He, X Zhang, J Tu - Cancer medicine, 2020 - Wiley Online Library
Background The prognostic and clinicopathological significance of POU Class 5 Homeobox
1 (POU5F1) among various cancers are disputable heretofore. The diagnostic value and …
1 (POU5F1) among various cancers are disputable heretofore. The diagnostic value and …
[HTML][HTML] MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer
MM Tsai, HW Huang, CS Wang, KF Lee, CY Tsai… - Oncotarget, 2016 - ncbi.nlm.nih.gov
MicroRNAs (miRNA) play an important role in carcinogenesis. Previously, we identified miR-
26b as a significantly downregulated miRNA in gastric cancer (GC) tissues (n= 106) based …
26b as a significantly downregulated miRNA in gastric cancer (GC) tissues (n= 106) based …
The prognostic value of whole blood, and mRNA expression in advanced small-cell lung cancer
Background. The data on expression and clinical impact of cancer stem cell markers SOX2,
NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare …
NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare …