In 1976 Ebola revealed itself to the world, marking the beginning of a series of localized
outbreaks. However, it was the Ebola outbreak that began in 2013 that incited fear and …

Virus infection affects cellular proteostasis and provides an opportunity to study this cellular
process under perturbation. The proteostasis network in the endoplasmic reticulum (ER) is …

Recently, people worldwide have experienced several outbreaks caused by viruses that
have attracted much interest globally, such as HIV, Zika, Ebola, and the one being faced …

Emerging and re-emerging viruses, such as Zaire Ebola virus (EBOV), pose a global threat
and require immediate countermeasures, including the rapid development of effective …

Accumulation of activated natural killer (NK) cells in tissues during Ebola virus infection
contributes to Ebola virus disease (EVD) pathogenesis. Yet, immunization with Ebola virus …

Lymphocyte depletion is a distinctive feature of Ebola virus (EBOV) disease. The
ectodomain of EBOV glycoprotein (GP) is cleaved off the surface of infected cells into …

RNA editing has been discovered as an essential mechanism for the transcription of the
glycoprotein (GP) gene of Ebola virus but not Marburg virus. We developed a rapid transcript …

Viruses can utilize host splicing machinery to enable the expression of multiple genes from a
limited-sized genome. Orthobornaviruses use alternative splicing to regulate the expression …

The mitogen-activated protein kinase (MEK) inhibitor zapnometinib is in development to
treat acute viral infections like COVID-19 and influenza. While the antiviral efficacy of …

The most recent Sudan virus (SUDV) outbreak in Uganda was first detected in September
2022 and resulted in 164 laboratory-confirmed cases and 77 deaths. There are no approved …