The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …

The fidelity of intracellular signaling hinges on the organization of dynamic activity
architectures. Spatial compartmentation was first proposed over 30 years ago to explain how …

Cells relay a plethora of extracellular signals to specific cellular responses by using only a
few second messengers, such as cAMP. To explain signaling specificity, cAMP-degrading …

The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …

G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

A plethora of cellular processes, including apoptosis, depend on regulated changes in
mitochondrial shape and ultrastructure. The role of mitochondria and of their morphology …

Bile acids are well-recognized stimuli of glucagon-like peptide-1 (GLP-1) secretion. This
action has been attributed to activation of the G protein–coupled bile acid receptor GPBAR1 …

A growing number of studies are revealing that cells can send and receive information by
controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we …