Mental disorders represent a worldwide public health concern. Psychotherapies and
pharmacotherapies are recommended as first line treatments. However, evidence has …

This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia seeks to reduce these substantial psychosocial and public health …

Background Schizophrenia is a common, severe, and usually chronic disorder. Maintenance
treatment with antipsychotic drugs can prevent relapse but also causes side-effects. We …

Background Antipsychotic treatment is associated with metabolic disturbance. However, the
degree to which metabolic alterations occur in treatment with different antipsychotics is …

Non-invasive brain stimulation (NIBS), including transcranial magnetic stimulation (TMS),
and transcranial direct current stimulation (tDCS), is a potentially effective treatment strategy …

Individuals diagnosed with schizophrenia or bipolar disorder have a life expectancy 15–20
years shorter than that in the general population. The rate of unnatural deaths, such as …

The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

Individuals with substance use disorders (SUDs) are at increased risk for COVID‐19
infection and for adverse outcomes of the infection. Though vaccines are highly effective …