[HTML][HTML] Potential therapeutic targets and vaccine development for SARS-CoV-2/COVID-19 pandemic management: a review on the recent update

U Anand, S Jakhmola, O Indari, HC Jha… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly pathogenic
novel virus that has caused a massive pandemic called coronavirus disease 2019 (COVID …

[HTML][HTML] Covid-19 and Artificial Intelligence: Genome sequencing, drug development and vaccine discovery

SA Bagabir, NK Ibrahim, HA Bagabir… - Journal of Infection and …, 2022 - Elsevier
Objectives To clarify the work done by using AI for identifying the genomic sequences,
development of drugs and vaccines for COVID-19 and to recognize the advantages and …

DeepDDS: deep graph neural network with attention mechanism to predict synergistic drug combinations

J Wang, X Liu, S Shen, L Deng… - Briefings in …, 2022 - academic.oup.com
Motivation Drug combination therapy has become an increasingly promising method in the
treatment of cancer. However, the number of possible drug combinations is so huge that it is …

Metal complexes as antiviral agents for SARS‐CoV‐2

J Karges, SM Cohen - ChemBioChem, 2021 - Wiley Online Library
The severe acute respiratory syndrome–coronavirus 2 (SARS‐CoV‐2), the infectious agent
responsible for COVID‐19–has caused more than 2.5 million deaths worldwide and …

The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2

I Ahmad - European journal of medicinal chemistry, 2021 - Elsevier
The unforeseen emergence of coronavirus disease 2019 (COVID-19), a severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) at the Wuhan province of China in …

Computational drug repurposing study of the RNA binding domain of SARS‐CoV‐2 nucleocapsid protein with antiviral agents

G Tatar, E Ozyurt, K Turhan - Biotechnology progress, 2021 - Wiley Online Library
The recent outbreak of coronavirus disease (COVID‐19) in China caused by the severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has led to worldwide human …

[HTML][HTML] In silico evaluation of potential inhibitory activity of remdesivir, favipiravir, ribavirin and galidesivir active forms on SARS-CoV-2 RNA polymerase

I Celik, M Erol, Z Duzgun - Molecular Diversity, 2021 - Springer
Since the outbreak emerged in November 2019, no effective drug has yet been found
against SARS-CoV-2. Repositioning studies of existing drug molecules or candidates are …

[HTML][HTML] Understanding viral infection mechanisms and patient symptoms for the development of COVID-19 therapeutics

HM Choi, SY Moon, HI Yang, KS Kim - International Journal of Molecular …, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, has become a
worldwide pandemic. Symptoms range from mild fever to cough, fatigue, severe pneumonia …

Novel piperazine based compounds as potential inhibitors for SARS-CoV-2 Protease Enzyme: Synthesis and molecular docking study

AZ Omar, TM Mosa, SK El-Sadany, EA Hamed… - Journal of Molecular …, 2021 - Elsevier
Structurally diverse piperazine-based compounds hybrid with thiadiazole, isatin or with
sulfur/nitrogen, functionalities were synthesized. The structures of the new compounds were …

Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives

A Pawełczyk, L Zaprutko - Future Medicinal Chemistry, 2020 - Future Science
At the end of 2019, a novel virus causing severe acute respiratory syndrome to spread
globally. There are currently no effective drugs targeting SARS-CoV-2. In this study, based …