The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Glucose is the main energy substrate for the brain. There is now extensive evidence
indicating that the metabolic profile of neural cells with regard to glucose utilization and …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia,
responsible for the onset of several long-term complications. Recent evidence suggests that …

The idea of the existence of an interaction between the immune system and the central
nervous system (CNS) has prompted extensive research interest into the subject of “ …

Diabetes mellitus is a multifactorial disease, classically influenced by genetic determinants
of individual susceptibility and by environmental accelerating factors, such as lifestyle. It is …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Neural tissue is one of the main oxygen consumers in the mammalian body, and a
plentitude of metabolic as well as signaling processes within the brain is accompanied by …

The glyoxalase pathway functions to detoxify reactive dicarbonyl compounds, most
importantly methylglyoxal. The glyoxalase pathway is an antioxidant defense mechanism …

Cognitive impairment (CI) associated with chronic kidney disease (CKD) has received
attention as an important problem in recent years. Causes of CI with CKD are multifactorial …