Malaria is caused by Plasmodium protozoa that are transmitted by anopheline mosquitoes.
Plasmodium sporozoites are released with saliva when an infected female mosquito takes a …

Parasites of the genus Plasmodium, the etiological agent of malaria, are transmitted through
the bite of anopheline mosquitoes, which deposit sporozoites into the host skin. Sporozoites …

Discovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …

Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …

Genetically engineered live Plasmodium falciparum sporozoites constitute a potential
platform for creating consistently attenuated, genetically defined, whole-parasite vaccines …

The circumsporozoite protein of the human malaria parasite Plasmodium falciparum
(PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in …

Human monoclonal antibodies (hmAbs) targeting the Plasmodium falciparum
circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for …

Combinations of monoclonal antibodies (mAbs) against different epitopes on the same
antigen synergistically neutralize many viruses. However, there are limited studies …

Rare and potent monoclonal antibodies (mAbs) against the Plasmodium falciparum (Pf)
circumsporozoite protein (CSP) on infective sporozoites (SPZ) preferentially bind the PfCSP …

A malaria vaccine that elicits long-lasting protection and is suitable for use in endemic areas
remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy …