Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

Abstract N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …

We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …

Importance Three-dimensional cerebral organoids generated from patient-derived induced
pluripotent stem cells (iPSCs) may be used to interrogate cellular-molecular underpinnings …

Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …

On observing schizophrenia from a clinical point of view up to its molecular basis, one may
conclude that this is likely to be one of the most complex human disorders to be …

Background Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role
in maintaining dendritic structure through its interaction with microtubules. In schizophrenia …

Human olfactory neurosphere-derived (ONS) cells have the potential to provide novel
insights into the cellular pathology of schizophrenia. We used discovery-based proteomics …

The prefrontal cortex (PFC) and its connections with other brain areas are crucial for
cognitive function. Cognitive impairments are one of the core symptoms associated with …

The advances in mass spectrometry based proteomics in the past 15 years have contributed
to a deeper appreciation of protein networks and the composition of functional synaptic …