Within‐host dynamics of SARS‐CoV‐2 infection: a systematic review and meta‐analysis

Z Du, S Wang, Y Bai, C Gao, EHY Lau… - Transboundary and …, 2022 - Wiley Online Library
Within‐host model specified by viral dynamic parameters is a mainstream tool to understand
SARS‐CoV‐2 replication cycle in infected patients. The parameter uncertainty further affects …

Molnupiravir when used alone seems to be safe and effective as outpatient COVID-19 therapy for hemodialyzed patients and kidney transplant recipients

P Poznański, H Augustyniak-Bartosik, A Magiera-Żak… - Viruses, 2022 - mdpi.com
Background: Molnupiravir demonstrated an in vitro antiviral activity against positive-sense
RNA viruses, including SARS-CoV-2. The study aimed to present the results of outpatient …

[HTML][HTML] Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a …

DL Wannigama, C Hurst, P Phattharapornjaroen… - …, 2024 - thelancet.com
Background Repurposed drugs with host-directed antiviral and immunomodulatory
properties have shown promise in the treatment of COVID-19, but few trials have studied …

Prevention and treatment strategies for kidney transplant recipients in the context of long-term existence of COVID-19

Z Zheng, H Sun, X Hu, Z Xuan, M Fu, Y Bai, Y Du… - Frontiers in …, 2024 - frontiersin.org
The sudden outbreak of coronavirus disease 2019 (COVID-19) in early 2020 posed a
massive threat to human life and caused an economic upheaval worldwide. Kidney …

Modeling the within-host dynamics of SARS-CoV-2 infection based on antiviral treatment

T Song, Y Wang, X Gu, S Qiao - Mathematics, 2023 - mdpi.com
The COVID-19 pandemic has highlighted the profound impact of the SARS-CoV-2 virus as a
significant threat to human health. There is an urgent need to develop a comprehensive …

Polymorphs and Solvates of Molnupiravir: Crystal Structures and Solid Forms Transformation Analysis

P Han, L Wang, S Song, C Yao, X Tao… - Crystal Growth & …, 2024 - ACS Publications
Molnupiravir (MPV) is a widely used oral anti-COVID-19 drug. Owing to the rotatable bonds
and the large number of acceptors and donors of hydrogen bonds in the molecular structure …

[HTML][HTML] Noncovalent SARS-COV-2 main protease inhibitors: A virtual screening and molecular dynamic simulation study

A Yan, W Li, X Zhao, R Cao, H Li, L Chen, X Li - Results in Chemistry, 2024 - Elsevier
The main severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease (M pro,
also known as 3CL pro) plays a central role in virus replication, thereby constituting an …

Assessing the Efficacy of Early Therapies against SARS-CoV-2 in Hematological Patients: A Real-Life Study from a COVID-19 Referral Centre in Northern Italy

M Colaneri, TC Pieri, S Roda, A Ricciardi… - Journal of Clinical …, 2022 - mdpi.com
Early therapies to prevent severe COVID-19 have an unclear impact on patients with
hematological malignancies. The aim of this study was to assess their efficacy in this group …

Avaliação da atividade antiviral e imunomoduladora do Zinco em modelo de infecção por SARS-CoV-2 in vitro

LIM Gomes - 2023 - repositorio.ufrn.br
RESUMO A infecção pelo SARS-CoV-2 pode desencadear uma resposta inflamatória
exacerbada, caracterizada pela atividade excessiva do sistema imunológico na tentativa de …

[引用][C] Kami nska, D. Molnupiravir When Used Alone Seems to Be Safe and Effective as Outpatient COVID-19 Therapy for Hemodialyzed Patients and Kidney …

H Augustyniak-Bartosik, A Magiera-Zak, K Skalec… - 2022 - europepmc.org
Background: Molnupiravir demonstrated an in vitro antiviral activity against positivesense
RNA viruses, including SARS-CoV-2. The study aimed to present the results of outpatient …