Accurate diagnosis of human diseases is crucial for effective prevention, clinical treatment,
and prognosis. The World Health Organization (WHO) has provided guidelines for molecular …

Infectious diseases (such as sepsis, influenza, and malaria), caused by various pathogenic
bacteria and viruses, are widespread across the world. Early and rapid detection of disease …

Foodborne pathogenic bacteria are recognized as the main causes of microbial
contamination in food safety. Early screening and ultrasensitive detection of foodborne …

Rapid and ultrasensitive point-of-care RNA detection plays a critical role in the diagnosis
and management of various infectious diseases. The gold-standard detection method of …

CRISPR-Cas12a can induce nonspecific trans-cleavage of dsDNA substrate, including long
and stable λ DNA. However, the mechanism behind this is still largely undetermined. In this …

Abstract clustered regularly interspaced short palindromic repeats (CRISPR)‐Cas systems
are increasingly used in biosensor development. However, directly translating recognition …

The increasing prevalence of antibiotic-resistant bacterial infections, particularly methicillin-
resistant Staphylococcus aureus (MRSA), presents a significant public health concern …

The CRISPR (Clustered Regularly Spaced Short Palindromic Repeats) system was first
discovered in prokaryotes as a unique immune mechanism to clear foreign nucleic acids. It …

The efficient cytosolic delivery of the CRISPR-Cas9 machinery remains a challenge for
genome editing. Herein, we performed ligand screening and identified a guanidinobenzol …

Rapid and sensitive detection of nucleic acids has become crucial in various fields.
However, most current nucleic acid detection methods can only be used in specific …