Mitochondrial antiviral signaling protein (MAVS) functions as a “switch” in the immune signal
transduction against most RNA viruses. Upon viral infection, MAVS forms prion-like …

Ubiquitination is a prominent posttranslational modification, in which the ubiquitin moiety is
covalently attached to a target protein to influence protein stability, interaction partner and …

Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes,
and the enzymes involved are tightly regulated by multiple factors including posttranslational …

Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions
as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor …

Lysosomal-dependent self-degradative (autophagic) mechanisms are essential for the
maintenance of normal homeostasis in all eukaryotic cells. Several types of such self …

Abstract IFN regulatory factor 3 (IRF3) is critical for the transcription of type I IFNs in
defensing virus and promoting inflammatory responses. Although several kinds of …

The innate immune system responds rapidly to protect against viral infections, but an
overactive response can cause harmful damage. To avoid this, the response is tightly …

SAMHD 1 possesses multiple functions, but whether cellular factors regulate SAMHD 1
expression or its function remains not well characterized. Here, by investigating why cultured …

Influenza A viruses (IAVs) continuously challenge the poultry industry and human health.
Elucidation of the host factors that modulate the IAV lifecycle is vital for developing antiviral …

Sensing of pathogen-associated molecular patterns including viral RNA by innate immunity
represents the first line of defense against viral infection. In addition to RIG-I-like receptors …