Ubiquitination is a common form of posttranslational modification that has been implicated in
regulating considerable immune signaling pathways. The functions of canonic K48-and K63 …

The pandemic coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), is currently the most formidable challenge to …

Long noncoding RNAs (lncRNAs) widely exist in the cells and play important roles in various
biological processes. The role of lncRNAs in immunity remains largely unknown. lncRNA …

Sarcoidosis is a multisystem disease characterized by the development and accumulation of
granulomas, the hallmark of an inflammatory process induced by environmental and/or …

Tripartite motif–containing protein 21 (TRIM21) is a cytosolic antibody receptor that targets
the internalized virus–antibody complex to the proteasome for degradation. However, the …

Abstract Tripartite motif 21 (TRIM21), a member of the TRIM family, plays an important role in
apoptosis, autophagy and ubiquitination in human, and has been proven to play antiviral …

In the host, many RING domain E3 ligases have been reported to inhibit viral replication
through various mechanisms. In a previous screen, we found that porcine RING finger …

The innate immune response is the first-line host defense against pathogens. Cytosolic
nucleic acids, including both DNA and RNA, represent a special type of danger signal to …

Porcine reproductive and respiratory syndrome (PRRS) causes substantial economic losses
to the global pig industry. Members of the tripartite motif (TRIM) family are the important …

The host always employs various ways to defend against viral infection and spread.
However, viruses have evolved their own effective strategies, such as inhibition of RNA …