The success of allogeneic stem cell transplantation and solid-organ transplantation owes
much to improvements in the immunosuppressive regimens that prevent graft-versus-host …

A key determinant for the survival of an organism is the ability to recognize and respond to
invading pathogens without damaging host tissues. This is accomplished largely by the …

IgG is the major immunoglobulin class produced during an immune response against
foreign antigens and efficiently provides protection through its bifunctional nature. While the …

The role of CD40/CD40 ligand (CD40L) interactions in atherothrombosis, in the response of
the immune system to pathogens and in thrombosis is now widely accepted. A role for CD40 …

Blockade of CD40–CD154 signaling pathway is an attractive strategy to induce potent
immunosuppression and tolerance in organ transplantation. Due to its strong …

Since the discovery of the CD40–CD154 costimulatory pathway and its critical role in the
adaptive immune response, there has been considerable interest in therapeutically targeting …

Transient thrombocytopenia is a common phenomenon after liver transplantation. After liver
transplantation (LT), platelet count decreases and reaches a nadir on postoperative days 3 …

Background. Polyclonal antithymocyte globulins (ATGs) are used clinically to prevent and
treat acute allograft rejection and are believed to modulate the immune response primarily …

Background. Ischemia-reperfusion injury (IRI) leads to increased leukocyte adherence
enhancing acute cellular rejection and microvascular dysfunction. Polyclonal antithymocyte …

Abstract Thymoglobulin (Genzyme Transplant, Cambridge, MA) is a polyclonal rabbit anti-
thymocyte globulin that consists of a mixture of different antibody specificities that interact …