Single‐cell RNA sequencing (scRNA‐seq) technology has become the state‐of‐the‐art
approach for unravelling the heterogeneity and complexity of RNA transcripts within …

Some of the biological knowledge obtained from fundamental research will be implemented
in applied plant breeding. To bridge basic research and breeding practice, machine learning …

Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …

Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma
cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …

The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising
therapies entering clinical translation, yet patient responses remain heterogeneous, and …

Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages
(MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We …

There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell
therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord …

We present an integrated analysis of the clinical measurements, immune cells, and plasma
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …

Diabetic kidney disease (DKD) occurs in∼ 40% of patients with diabetes and causes kidney
failure, cardiovascular disease, and premature death. We analyzed the response of a …

Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …