Legacy benefits of blood glucose, blood pressure and lipid control in individuals with diabetes and cardiovascular disease: time to overcome multifactorial therapeutic …
Cardiovascular disease is a major cause of morbidity and mortality globally and the largest
contributor to healthcare costs. There is good evidence that management of risk factors such …
contributor to healthcare costs. There is good evidence that management of risk factors such …
Follow-up of blood-pressure lowering and glucose control in type 2 diabetes
Background In the Action in Diabetes and Vascular Disease: Preterax and Diamicron
Modified Release Controlled Evaluation (ADVANCE) factorial trial, the combination of …
Modified Release Controlled Evaluation (ADVANCE) factorial trial, the combination of …
Long-term mortality after blood pressure-lowering and lipid-lowering treatment in patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial …
A Gupta, J Mackay, A Whitehouse, T Godec, T Collier… - The Lancet, 2018 - thelancet.com
Background In patients with hypertension, the long-term cardiovascular and all-cause
mortality effects of different blood pressure-lowering regimens and lipid-lowering treatment …
mortality effects of different blood pressure-lowering regimens and lipid-lowering treatment …
The long-term benefits of early intensive therapy in chronic diseases—the legacy effect
The 'legacy effect'refers to the long-term benefits of intensive therapy that are observed long
after the end of clinical trials and trial interventions in chronic diseases such as diabetes …
after the end of clinical trials and trial interventions in chronic diseases such as diabetes …
Legacy benefits of blood pressure treatment on cardiovascular events are primarily mediated by improved blood pressure variability: the ASCOT trial
A Gupta, WN Whiteley, T Godec… - European Heart …, 2024 - academic.oup.com
Abstract Background and Aims Visit-to-visit systolic blood pressure variability (BPV) is an
important predictor of cardiovascular (CV) outcomes. The long-term effect of a period of …
important predictor of cardiovascular (CV) outcomes. The long-term effect of a period of …
Association between chlorthalidone treatment of systolic hypertension and long-term survival
Context In the Systolic Hypertension in the Elderly Program (SHEP) trial, conducted between
1985 and 1990, antihypertensive therapy with chlorthalidone-based stepped-care therapy …
1985 and 1990, antihypertensive therapy with chlorthalidone-based stepped-care therapy …
Cost-effectiveness of community-based strategies for blood pressure control in a low-income developing country: findings from a cluster-randomized, factorial …
Background—Evidence on economically efficient strategies to lower blood pressure (BP)
from low-and middle-income countries remains scarce. The Control of Blood Pressure and …
from low-and middle-income countries remains scarce. The Control of Blood Pressure and …
Clinical effect of naturally random allocation to lower systolic blood pressure beginning before the development of hypertension
BA Ference, S Julius, N Mahajan, PD Levy… - …, 2014 - Am Heart Assoc
Systolic blood pressure (SBP) rises approximately linearly with age in most societies. The
cause of this rise is unclear. We tested the hypothesis that SBP is causally associated with …
cause of this rise is unclear. We tested the hypothesis that SBP is causally associated with …
Novel angiotensin I-converting enzyme inhibitory peptide derived from bovine casein
A Yamada, T Sakurai, D Ochi, E Mitsuyama… - Food chemistry, 2013 - Elsevier
Bovine lactic casein was hydrolysed using a combination of three enzymes, namely,
subtilisin, bacillolysin, and trypsin, and the resulting preparation was coined CH-3. CH-3 …
subtilisin, bacillolysin, and trypsin, and the resulting preparation was coined CH-3. CH-3 …
Antihypertensive effect of the bovine casein-derived peptide Met-Lys-Pro
A Yamada, T Sakurai, D Ochi, E Mitsuyama… - Food Chemistry, 2015 - Elsevier
The antihypertensive effect of the bovine casein-derived peptide Met-Lys-Pro (MKP) was
examined in vitro and in vivo. MKP showed angiotensin I-converting enzyme (ACE) …
examined in vitro and in vivo. MKP showed angiotensin I-converting enzyme (ACE) …