Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

In this Opinion article, we summarize how changes in DNA methylation occur during aging
in mammals and discuss examples of how such events may contribute to the aging process …

In mammals, caloric restriction consistently results in extended lifespan. Epigenetic
information encoded by DNA methylation is tightly regulated, but shows a striking drift …

Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …

Increased age, BMI and HbA1c levels are risk factors for several non-communicable
diseases. However, the impact of these factors on the genome-wide DNA methylation …

In recent years, biomarkers have been integrated into the diagnostic process and have
become increasingly indispensable for obtaining knowledge of the neurodegenerative …

Background Epigenome-wide association studies (EWAS) based on human brain samples
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …

Background The well-established association of chronological age with changes in DNA
methylation is primarily founded on the analysis of large sets of blood samples, while …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …