The representation of distinct spaces by hippocampal place cells has been linked to
changes in their place fields (the locations in the environment where the place cells …

Astrocytes are emerging as key regulators of cognitive function and behavior. This review
highlights some of the latest advances in the understanding of astrocyte roles in different …

In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-
INs) play a prominent role in disinhibitory circuit motifs. However, the specific behavioral …

Background Despite several hundred clinical trials of drugs that initially showed promise,
there has been limited clinical improvement in Alzheimer's disease (AD). This may be …

Background Depressive symptoms often occur in patients with Alzheimer's disease (AD) and
exacerbate the pathogenesis of AD. However, the neural circuit mechanisms underlying the …

Spatial memory in the hippocampus involves dynamic neural patterns that change over
days, termed representational drift. While drift may aid memory updating, excessive drift …

Stress is an important initiating factor in promoting Alzheimer's disease (AD) pathogenesis.
However, the mechanism by which stress induces AD-like cognitive impairment remains to …

Background Dementia, a major symptom of several neurodegenerative diseases, can be
improved by acetylcholinesterase inhibitors (AChE); however, due to the complex etiology …

The hippocampus is an allocortex structure involved in many complex processes, from
memory formation to spatial navigation. It starts developing during prenatal life but acquires …

Age-related decline in physical and cognitive functions are facts of life that do not affect
everyone to the same extent. We had reported earlier that such cognitive decline is both sex …