Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design
G Bahr, LJ Gonzalez, AJ Vila - Chemical reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …
spread of genes coding for resistance determinants among bacteria challenges the use of …
Metallo-β-lactamases: structure, function, epidemiology, treatment options, and the development pipeline
SE Boyd, DM Livermore, DC Hooper… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …
[HTML][HTML] Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria
Antimicrobial resistance has been a global health challenge that threatens our ability to
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …
Antibiotic adjuvants: a versatile approach to combat antibiotic resistance
The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …
Current status and recent research achievements in SiC/SiC composites
The silicon carbide fiber-reinforced silicon carbide matrix (SiC/SiC) composite system for
fusion applications has seen a continual evolution from development a fundamental …
fusion applications has seen a continual evolution from development a fundamental …
Ten years with New Delhi metallo-β-lactamase-1 (NDM-1): from structural insights to inhibitor design
The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a
carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized …
carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized …
β-lactam/β-lactamase inhibitor combinations: an update
KHME Tehrani, NI Martin - Medchemcomm, 2018 - pubs.rsc.org
Antibiotic resistance caused by β-lactamase production continues to present a growing
challenge to the efficacy of β-lactams and their role as the most important class of clinically …
challenge to the efficacy of β-lactams and their role as the most important class of clinically …
Metallo-ß-lactamases: a review
Microbial pathogens including Enterobacteriaceae family members bear different antibiotic
resistance genes comprising Extended-Spectrum-ß-Lactamases (ESBLs) and Metallo-ß …
resistance genes comprising Extended-Spectrum-ß-Lactamases (ESBLs) and Metallo-ß …
The continuing challenge of metallo-β-lactamase inhibition: mechanism matters
Metallo-β-lactamases (MBLs) are a significant clinical problem because they hydrolyze and
inactivate nearly all β-lactam-containing antibiotics. These 'lifesaving drugs' constitute> 50 …
inactivate nearly all β-lactam-containing antibiotics. These 'lifesaving drugs' constitute> 50 …
Metallo-β-lactamase inhibitors inspired on snapshots from the catalytic mechanism
β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low
toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms …
toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms …