Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

The Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated
protein 9 (CRISPR/Cas9) system, an RNA-based adaptive immune system found in bacteria …

Breast cancer, the most frequent female malignancy, is often curable when detected at an
early stage. The treatment of metastatic breast cancer is more challenging and may be …

Chimeric antigen receptor (CAR)-immune cell therapy has revolutionized the anti-tumor
field, achieving efficient and precise tumor clearance by directly guiding immune cell activity …

Endogenous T cell activation relies on recognizing tumor‐specific antigens. However, tumor
cells often alter phenotypes to evade immune surveillance, resulting in immune escape and …

TCR-engineered T cells have achieved great progress in solid tumor therapy, some of which
have been applicated in clinical trials. Deep knowledge about the current progress of TCR-T …

NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant
potential for managing inflammatory disorders like asthma. Activating iNKT induces …

Chimeric antigen receptor-natural killer (CAR-NK) cell therapy is a novel immunotherapy
targeting cancer cells via the generation of chimeric antigen receptors on NK cells which …

Comprising only 1-10% of the circulating T cell population, γδT cells play a pivotal role in
cancer immunotherapy due to their unique amalgamation of innate and adaptive immune …

Simple Summary Chimeric antigen receptor T (CAR-T) therapy has revolutionized cancer
immunotherapy by inducing a durable response in patients with acute lymphoblastic …