Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal
agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably …

Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …

Understanding protective immunity to COVID-19 facilitates preparedness for future
pandemics and combats new SARS-CoV-2 variants emerging in the human population …

Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …

Life-threatening “breakthrough” cases of critical COVID-19 are attributed to poor or waning
antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting …

The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …

Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical
outcomes ranging from asymptomatic to severe disease and death. We previously reported …

Down's syndrome (DS) presents with a constellation of cardiac, neurocognitive and growth
impairments. Individuals with DS are also prone to severe infections and autoimmunity …

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines
underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare …