Type I and III interferons (IFN-I/λ) are important antiviral mediators against SARS-CoV-2
infection. Here, we demonstrate that plasmacytoid dendritic cells (pDC) are the predominant …

Coronavirus disease 2019 in children presents with milder clinical manifestations than in
adults. On the other hand, the presence of a wide range of inflammatory manifestations …

The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …

Autoantibodies neutralizing the antiviral action of type I interferons (IFNs) have been
associated with predisposition to severe Coronavirus Disease 2019 (COVID-19). Here, we …

Anti-cytokine autoantibodies (ACAAs) are increasingly recognized as modulating disease
severity in infection, inflammation and autoimmunity. By reducing or augmenting cytokine …

Objectives Type-I interferons (IFNs-I) have potent antiviral effects. IFNs-I are also
overproduced in patients with systemic lupus erythematosus (SLE). Autoantibodies (AAbs) …

Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2
condition (PASC) that persists for months after infection. Here we evaluate the immune …

This article provides an overview of various aspects related to post-COVID syndrome. Apart
from its prevalence, symptoms and sequelae, risk determinants, and psychosocial …

Abstract Background Interferons (IFNs) play a crucial role in antiviral immunity. Genetic
defects in interferon receptors, IFNs, and auto-antibodies against IFNs can lead to the …

In 1955, René Dubos famously expressed his “second thoughts on the germ theory”,
attributing infectious diseases to various “changing circumstances” that weaken the host by …