We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …

ABSTRACT Introduction Post-COVID syndrome (PCS) is recognized as a new entity in the
context of SARS-CoV-2 infection. Though its pathogenesis is not completely understood …

Immunity to infection has been extensively studied in humans and mice bearing naturally
occurring or experimentally introduced germline mutations. Mouse studies are sometimes …

Background Understanding the complexities of immune memory to severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is key to gain insights into the durability of protective …

Long COVID (LC) encompasses a constellation of long-term symptoms experienced by at
least 10% of people after the initial SARS-CoV-2 infection, and so far it has affected about 65 …

Globally, autosomal recessive IFNAR1 deficiency is a rare inborn error of immunity
underlying susceptibility to live attenuated vaccine and wild-type viruses. We report seven …

We review the characteristics of SARS-CoV-2 infection in a large number of patients with IEI.
Overall, we found that combined immunodeficiencies, immune dysregulation disorders, and …

Acute COVID-19, caused by SARS-CoV-2, is characterized by diverse clinical presentations,
ranging from asymptomatic infection to fatal respiratory failure, and often associated with …

The emergence of persistent ill-health in the aftermath of SARS-CoV-2 infection has
presented significant challenges to patients, healthcare workers and researchers. Termed …

An increase in the incidence of inflammatory arthritis after COVID-19 has been reported.
Since many diseases exhibit population-specific causal effect sizes, we aimed to evaluate …