Compilation of reported protein changes in the brain in Alzheimer's disease
M Askenazi, T Kavanagh, G Pires… - Nature …, 2023 - nature.com
Proteomic studies of human Alzheimer's disease brain tissue have potential to identify
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …
On the potential of micro-flow LC-MS/MS in proteomics
Introduction Due to its excellent sensitivity, nano-flow liquid chromatography tandem mass
spectrometry (LC-MS/MS) is the mainstay in proteome research; however, this comes at the …
spectrometry (LC-MS/MS) is the mainstay in proteome research; however, this comes at the …
[HTML][HTML] Management of inherited CNS small vessel diseases: the CADASIL example: a scientific statement from the American Heart Association
Lacunar infarcts and vascular dementia are important phenotypic characteristics of cerebral
autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, the …
autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, the …
Distinct brain proteomic signatures in cerebral small vessel disease rat models of hypertension and cerebral amyloid angiopathy
JM Schrader, A Stanisavljevic, F Xu… - … of Neuropathology & …, 2022 - academic.oup.com
Cerebral small vessel diseases (CSVDs) are prominent contributors to vascular cognitive
impairment and dementia and can arise from a range of etiologies. Cerebral amyloid …
impairment and dementia and can arise from a range of etiologies. Cerebral amyloid …
Localized proteomic differences in the choroid plexus of Alzheimer's disease and epilepsy patients
DF Leitner, E Kanshin, A Faustin, M Thierry… - Frontiers in …, 2023 - frontiersin.org
Introduction Alzheimer's disease (AD) and epilepsy are reciprocally related. Among sporadic
AD patients, clinical seizures occur in 10–22% and subclinical epileptiform abnormalities …
AD patients, clinical seizures occur in 10–22% and subclinical epileptiform abnormalities …
Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats
JM Schrader, F Xu, KJ Agostinucci, NA DaSilva… - Scientific Reports, 2024 - nature.com
Cerebral amyloid angiopathy (CAA) is a prevalent vascular dementia and common
comorbidity of Alzheimer's disease (AD). While it is known that vascular fibrillar amyloid β …
comorbidity of Alzheimer's disease (AD). While it is known that vascular fibrillar amyloid β …
[HTML][HTML] Lysosomal proteomics reveals mechanisms of neuronal apoE4associated lysosomal dysfunction
ApoE4 is the primary risk factor for Alzheimer's Disease. While apoE is primarily expressed
by astrocytes, AD pathology including endosomal abnormalities and mitochondrial …
by astrocytes, AD pathology including endosomal abnormalities and mitochondrial …
Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease
We report a highly significant correlation in brain proteome changes between Alzheimers
disease (AD) and CRND8 APP695NL/F transgenic mice. However, integrating protein …
disease (AD) and CRND8 APP695NL/F transgenic mice. However, integrating protein …
Proteomic changes in the human cerebrovasculature in Alzheimer's disease and related tauopathies linked to peripheral biomarkers in plasma and cerebrospinal fluid
INTRODUCTION Cerebrovascular dysfunction is a pathological hallmark of Alzheimer's
disease (AD). Nevertheless, detecting cerebrovascular changes within bulk tissues has …
disease (AD). Nevertheless, detecting cerebrovascular changes within bulk tissues has …
Compilation of all known protein changes in the human Alzheimer's disease brain
M Askenazi, T Kavanagh, G Pires, B Ueberheide… - bioRxiv, 2023 - biorxiv.org
Proteomic studies of human Alzheimer's disease brain tissue have exceptional potential to
identify protein changes that drive disease and to identify new drug targets. Here, we detail a …
identify protein changes that drive disease and to identify new drug targets. Here, we detail a …