The emergence of NDM-1 containing multi-antibiotic resistant" Superbugs" necessitates the
needs of developing of novel NDM-1inhibitors. In this study, we report the discovery of novel …

Due to the global threat of antibiotic resistance mediated by New Delhi metallo-beta-
lactamase-1 (NDM-1) and the lack of structurally diverse inhibitors reported for this enzyme …

Objective This study was performed to investigate the prevalence of multidrug resistance
and molecular characterization of Klebsiella pneumoniae (KPN) from clinical isolates in the …

The superbug infection caused by New Delhi metallo-β-lactamase (NDM-1) has grown into
an emerging threat, labelling and inhibition of NDM-1 has proven challenging due to its …

Bacterial expression of β‐lactamases, which hydrolyze β‐lactam antibiotics, contributes to
the growing threat of antibacterial drug resistance. Metallo‐β‐lactamases, such as NDM‐1 …

Metallo-β-lactamases (MBLs) are class B β-lactamases from the metallo-hydrolase-like MBL-
fold superfamily which act on a broad range of β-lactam antibiotics. A previous study on …

Staphylococcus aureus clonal complex CC30 has caused infectious epidemics for more
than 60 years, and, therefore, provides a model system to evaluate how evolution has …

New Delhi metallo-β-lactamase (NDM-1), one of the metallo-β-lactamases (MBLs), leads to
antibiotic resistance in clinical treatments due to the strong ability of hydrolysis to almost all …

New Delhi metallo-β-lactamase (NDM-1) is a new metallo-β-lactamase (MBL) that has
recently emerged as a global threat because it confers bacteria with resistance to almost all …

Metallo-β-lactamases can hydrolyze and deactivate lactam-containing antibiotics, which is
the major mechanism for causing drug resistance in the treatment of bacterial infections …