Being the second leading cause of death and the leading cause of disability-adjusted life
years worldwide, infectious diseases remain─ contrary to earlier predictions─ a major …

NDM-1 can hydrolyze nearly all available β-lactam antibiotics, including carbapenems. NDM-
1 producing bacterial strains are worldwide threats. It is still very challenging to find a potent …

ABSTRACT The New Delhi metallo-β-lactamase-1 (NDM-1) enzyme is the most common
metallo-β-lactamase identified in many Gram-negative bacteria causing severe nosocomial …

A new member of the class metallo-β-lactamase (MBL), New Delhi metallo-beta-lactamase 1
(NDM-1) has emerged recently as a leading threat to the treatment of infections that have …

Surface functionalization has attracted considerable interest from researchers because of its
capability for facilitating the interface communication between an energy transducer and a …

Mutations can have deleterious fitness effects when they decrease protein specific activity or
decrease active protein abundance. Mutations will also be deleterious when they cause …

Four NDM-1 mutants (L218T, L221T, L269H and L221T/Y229W) were generated in order to
investigate the role of leucines positioned in L10 loop. A detailed kinetic analysis stated that …

New Delhi metallo-β-lactamase 1 (NDM-1) is a key enzyme that the pathogen Klebsiella
pneumonia uses to hydrolyze almost all β-lactam antibiotics. It is currently unclear why NDM …

In an effort to probe the biophysical mechanisms of inhibition for ten previously-reported
inhibitors of metallo-β-lactamases (MBL) with MBL IMP-1, equilibrium dialysis, metal …

Andai sel-sel dalam tubuh bisa bicara, telinga kita pasti pengang akan segala kegaduhan
dan perang yang terjadi di dalam. Untung saja mereka bekerja keras dalam senyap, sekuat …