Pharmacological blockage of ICAM-1 improves angiotensin II-induced cardiac remodeling by inhibiting adhesion of LFA-1+ monocytes

QY Lin, PP Lang, YL Zhang, XL Yang… - American Journal …, 2019 - journals.physiology.org
Intercellular adhesion molecule-1 (ICAM-1) is a member of an immunoglobulin-like
superfamily of adhesion molecules that mediate leukocyte adhesion to vascular …

Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?

JP Williams, CJ Johnston… - Current drug targets, 2010 - ingentaconnect.com
Due to the radiosensitivity of the lung, toxic endpoints, in the form of radiation pneumonitis
and pulmonary fibrosis, are relatively frequent outcomes following radiation treatment of …

[PDF][PDF] NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype

R Dworakowski, SP Alom-Ruiz, AM Shah - Pharmacological Reports, 2008 - academia.edu
Endothelial dysfunction comprising impairment of endothelium-dependent vasodilator
function and increased endothelial activation contributes to the pathophysiology of …

Pressure-independent effects of angiotensin II on hypertensive myocardial fibrosis

K Tokuda, H Kai, F Kuwahara, H Yasukawa… - …, 2004 - Am Heart Assoc
Angiotensin II (Ang II) is implicated in the proinflammatory process in various disease
situations. Thus, we sought to determine the role of Ang II in early inflammation-induced …

Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis

M Sata, D Fukuda - The Journal of Medical Investigation, 2010 - jstage.jst.go.jp
The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the
initiation and progression of atherosclerosis, thereby contributing to development of …

Increased incidence but lack of association between cardiovascular risk factors in adults born preterm

A Flahault, K Paquette, RO Fernandes, J Delfrate… - …, 2020 - Am Heart Assoc
Preterm birth incurs an increased risk of early cardiovascular events and death. In the
general population, cardiovascular risk factors cluster in the context of inflammation and …

[HTML][HTML] Angiotensin-(1-7) attenuates angiotensin II-induced ICAM-1, VCAM-1, and MCP-1 expression via the MAS receptor through suppression of P38 and NF-κB …

B Liang, X Wang, N Zhang, H Yang, R Bai… - Cellular Physiology and …, 2015 - karger.com
Background/Aims: Atherosclerosis is a chronic inflammatory disease. Intracellular adhesion
molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and monocyte …

Endothelial activation by angiotensin II through NFκB and p38 pathways: Involvement of NFκB‐inducible kinase (NIK), free oxygen radicals, and selective inhibition by …

A Costanzo, F Moretti, VL Burgio… - Journal of cellular …, 2003 - Wiley Online Library
Abstract Angiotensin‐II (AII), the dominant effector of the renin–angiotensin system, is
involved in the pathogenesis of cardiovascular diseases, such as atherosclerosis …

[HTML][HTML] Renin-angiotensin system activation correlates with microvascular dysfunction in a prospective cohort study of clinical sepsis

KC Doerschug, AS Delsing, GA Schmidt, A Ashare - Critical Care, 2010 - Springer
Introduction Microvascular dysregulation characterized by hyporesponsive vessels and
heterogeneous bloodflow is implicated in the pathogenesis of organ failure in sepsis. The …

Blockade of intercellular adhesion molecule-1 prevents angiotensin II-induced hypertension and vascular dysfunction

PP Lang, J Bai, YL Zhang, XL Yang, YL Xia… - Laboratory …, 2020 - nature.com
Monocyte and adhesion infiltration into the arterial subendothelium are initial steps in
hypertension development. The endothelial intercellular adhesion molecule-1 (ICAM-1) has …