Macrophages have an important role in the pathogenesis of hypertension and associated
end-organ damage via the activation of the Toll-like receptors, such as Toll-like receptor-4 …

Endothelial activation refers to a specific change in endothelial phenotype, characterized
most notably by an increase in endothelial–leukocyte interactions and permeability, which is …

Inflammation and activation of the immune system are key molecular and cellular events in
the pathogenesis of cardiovascular diseases, including atherosclerosis, hypertension …

Increased vascular superoxide production has now been demonstrated in many different
experimental models of hypertension, including spontaneous hypertensive rats Ž. wx SHRs …

Endothelial dysfunction and inflammation enhance vulnerability to hypertensive brain
damage. To explore the participation of Angiotensin II (Ang II) in the mechanism of …

NF-κB is a transcription factor whose nuclear residence is controlled by IκB family members.
In the NF-κB-IκB autoregulatory loop, activated (nuclear) Rel A· NF-κB1 induces the …

Chronic inflammation is a pathogenic feature of atherosclerosis and cardiovascular disease
mediated by substances including angiotensin II, proinflammatory cytokines, and free fatty …

Atherosclerosis is a chronic inflammatory process. The adhesion of leukocytes to the
vascular endothelium, mediated by endothelial cell adhesion molecules including vascular …

The aim of the study was to examine whether the circulating cell adhesion molecules, von
Willebrand factor (vWf) and endothelin-1, are elevated in patients with essential …

Background: Sepsis is a life-threatening condition responsible for up to 20% of all global
deaths. Kidneys are among the most common organs implicated, yet the pathogenesis of …