The kidney proximal tubule (PT) elaborates a uniquely high-capacity apical endocytic
pathway to retrieve albumin and other proteins that escape the glomerular filtration barrier …

APOL1 harbors C–terminal sequence variants (G1 and G2), which account for much of the
increased risk for kidney disease in sub–Saharan African ancestry populations. Expression …

The discovery of the transforming growth factor β (TGF-β) family ligands and the realization
that their bioactivities need to be tightly controlled temporally and spatially led to intensive …

Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent
pathologies with complex aetiologies. One hallmark of renal lipotoxicity is the ectopic …

Steroid-resistant nephrotic syndrome is characterized by podocyte dysfunction. Drosophila
garland cell nephrocytes are podocyte-like cells and thus provide a potential in vivo model …

Diabetic nephropathy is a major cause of end-stage kidney disease. Characterized by
progressive microvascular disease, most efforts have focused on injury to the glomerular …

In the current review, we discuss limitations and recent advances in animal models of
diabetic nephropathy (DN). As in human disease, genetic factors may determine disease …

Expression quantitative trait locus (eQTL) studies illuminate genomic variants that regulate
specific genes and contribute to fine-mapped loci discovered via genome-wide association …

Chronic kidney disease (CKD) affects> 10% of the world population, with increasing
prevalence in middle age. The risk for CKD is dependent on the number of functioning …

Risk variants of the apolipoprotein-L1 (APOL1) gene are associated with severe kidney
disease, putting homozygous carriers at risk. Since APOL1 lacks orthologs in all major …