The role of extracellular vesicles in cancer

R Kalluri, KM McAndrews - Cell, 2023 - cell.com
Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Nanoparticle-based delivery systems for vaccines

R Bezbaruah, VP Chavda, L Nongrang, S Alom… - Vaccines, 2022 - mdpi.com
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional
vaccinations may have low immunogenicity and, in most situations, only provide partial …

Accelerating the prediction and discovery of peptide hydrogels with human-in-the-loop

T Xu, J Wang, S Zhao, D Chen, H Zhang… - Nature …, 2023 - nature.com
The amino acid sequences of peptides determine their self-assembling properties. Accurate
prediction of peptidic hydrogel formation, however, remains a challenging task. This work …

Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity

M Liu, S Hu, N Yan, KD Popowski, K Cheng - Nature Nanotechnology, 2024 - nature.com
Lung carcinoma is one of the most common cancers and has one of the lowest survival rates
in the world. Cytokines such as interleukin-12 (IL-12) have demonstrated considerable …

Combinatorial development of nebulized mRNA delivery formulations for the lungs

AY Jiang, J Witten, IO Raji, F Eweje, C MacIsaac… - Nature …, 2024 - nature.com
Inhaled delivery of mRNA has the potential to treat a wide variety of diseases. However,
nebulized mRNA lipid nanoparticles (LNPs) face several unique challenges including …

Stem cell-derived exosome versus stem cell therapy

K Zhang, K Cheng - Nature Reviews Bioengineering, 2023 - nature.com
Stem cell therapies are being explored for the treatment of various diseases, including
haematological disease, immune disease, neurodegenerative disease, and tissue injuries …

Nanotechnology's frontier in combatting infectious and inflammatory diseases: prevention and treatment

Y Huang, X Guo, Y Wu, X Chen, L Feng, N Xie… - … and Targeted Therapy, 2024 - nature.com
Inflammation-associated diseases encompass a range of infectious diseases and non-
infectious inflammatory diseases, which continuously pose one of the most serious threats to …

Chemically engineering cells for precision medicine

Y Wang, Z Li, F Mo, TJ Chen-Mayfield, A Saini… - Chemical Society …, 2023 - pubs.rsc.org
Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

[HTML][HTML] Guidelines for clinical translation and commercialization of extracellular vesicles and exosomes based therapeutics

K Cheng, R Kalluri - Extracellular Vesicle, 2023 - Elsevier
Extracellular vesicles (EVs) are lipid-bilayer delimited membrane structures released by
cells, and play a role in intercell communication and disease development. The Global …

Neoantigens: promising targets for cancer therapy

N Xie, G Shen, W Gao, Z Huang, C Huang… - Signal transduction and …, 2023 - nature.com
Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …