Knowing the precise locations of nucleosomes in a genome is key to understanding how
genes are regulated. Recent'next generation'ChIP–chip and ChIP–Seq technologies have …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

ATP-dependent chromatin-remodeling complexes are known to facilitate transcriptional
activation by opening chromatin structures. We report a novel human complex, named …

The importance of histones and chromatin structure in the regulation of eukaryotic gene
transcription has become much more widely accepted over the past few years. It has been …

Chromatin disruption and modification are associated with transcriptional regulation by
diverse coactivators and corepressors. Here we discuss the possible structural basis and …

The nuclear receptor PPARγ is a master regulator of adipogenesis. PPARγ is highly
expressed in adipose tissues and its expression is markedly induced during adipogenesis …

Post-translational modifications of the histone tails are correlated with distinct chromatin
states that regulate access to DNA. Recent proteomic analyses have revealed several new …

▪ Abstract The last two decades have witnessed a tremendous expansion in our knowledge
of the mechanisms employed by eukaryotic cells to control gene activity. A critical insight to …

Post‐translational acetylation of histone H4 N‐terminal tail in chromatin has been
associated with several nuclear processes including transcription. We report the purification …

ATRX syndrome is characterized by X-linked mental retardation associated with α-
thalassemia. The gene mutated in this disease, ATRX, encodes a plant homeodomain-like …