[HTML][HTML] Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

[HTML][HTML] Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

[HTML][HTML] SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

[HTML][HTML] N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease

X Wang, J Xie, L Tan, Y Lu, N Shen, J Li, H Hu… - Translational …, 2023 - Springer
Background Synaptic degeneration occurs in the early stage of Alzheimer's disease (AD)
before devastating symptoms, strongly correlated with cognitive decline. Circular RNAs …

Aerobic exercise regulates GPR81 signal pathway and mediates complement-microglia axis homeostasis on synaptic protection in the early stage of Alzheimer's …

J Yang, S Yuan, Y Jian, Y Lei, Z Hu, Q Yang, X Yan… - Life Sciences, 2023 - Elsevier
Aims Memory impairment is a major clinical manifestation in Alzheimer's disease (AD)
patients, while regular exercise may prevent and delay degenerative changes in memory …

Jacob‐induced transcriptional inactivation of CREB promotes Aβ‐induced synapse loss in Alzheimer's disease

KM Grochowska, GM Gomes, R Raman… - The EMBO …, 2023 - embopress.org
Synaptic dysfunction caused by soluble β‐amyloid peptide (Aβ) is a hallmark of early‐stage
Alzheimer's disease (AD), and is tightly linked to cognitive decline. By yet unknown …

[HTML][HTML] The environmental enrichment ameliorates chronic cerebral hypoperfusion-induced cognitive impairment by activating autophagy signaling pathway and …

L Xu, C Qu, Y Liu, H Liu - Brain Research Bulletin, 2023 - Elsevier
Background Chronic cerebral hypoperfusion (CCH) is a frequently observed underlying
pathology of both Alzheimer's disease (AD) and vascular dementia (VD), which is a common …

[HTML][HTML] Recent mechanisms of neurodegeneration and photobiomodulation in the context of Alzheimer's disease

M Su, D Nizamutdinov, H Liu, JH Huang - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease and the world's primary cause of
dementia, a condition characterized by significant progressive declines in memory and …

[HTML][HTML] Salivary Biomarkers for Alzheimer's Disease: A Systematic Review with Meta-Analysis

K Nijakowski, W Owecki, J Jankowski… - International Journal of …, 2024 - mdpi.com
Alzheimer's Disease (AD) is the most common neurodegenerative disease which manifests
with progressive cognitive impairment, leading to dementia. Considering the noninvasive …

Phenyl-quinoline derivatives as lead structure of cholinesterase inhibitors with potency to reduce the GSK-3β level targeting Alzheimer's disease

M Noori, N Dastyafteh, S Safapoor, MK Ghomi… - International Journal of …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that leads to cognitive decline
and memory loss. Unfortunately, there is no effective treatment for this condition, so there is …