Emerging SARS-CoV-2 variants of concern and potential intervention approaches

J Khateeb, Y Li, H Zhang - Critical Care, 2021 - Springer
The major variant of concerns (VOCs) have shared mutations in severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in …

Human organoid models to study SARS-CoV-2 infection

Y Han, L Yang, LA Lacko, S Chen - Nature Methods, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …

[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients

TW Kragstrup, HS Singh, I Grundberg, ALL Nielsen… - PloS one, 2021 - journals.plos.org
Aims Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin
converting enzyme 2 (ACE2) enabling entrance of the virus into cells and causing the …

SARS-CoV-2 variants and COVID-19 vaccines: Current challenges and future strategies

W Gong, S Parkkila, X Wu… - International reviews of …, 2023 - Taylor & Francis
The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has become a global threat. Despite strict control measures …

The impact of ACE2 polymorphisms on COVID-19 disease: susceptibility, severity, and therapy

F Chen, Y Zhang, X Li, W Li, X Liu… - Frontiers in Cellular and …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has currently spread worldwide, leading to high morbidity and …

Organoids: The current status and biomedical applications

S Yang, H Hu, H Kung, R Zou, Y Dai, Y Hu… - MedComm, 2023 - Wiley Online Library
Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

Y Chen, L Sun, I Ullah, G Beaudoin-Bussières… - Science …, 2022 - science.org
Soluble angiotensin-converting enzyme 2 (ACE2) constitutes an attractive antiviral capable
of targeting a wide range of coronaviruses using ACE2 as their receptor. Using structure …

Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19

K Kuba, T Yamaguchi, JM Penninger - Frontiers in immunology, 2021 - frontiersin.org
Seventeen years after the epidemic of SARS coronavirus, a novel coronavirus SARS-CoV-2-
emerged resulting in an unprecedented pandemic. Angiotensin-converting enzyme 2 …

Evidence for and against direct kidney infection by SARS-CoV-2 in patients with COVID-19

L Hassler, F Reyes, MA Sparks… - Clinical Journal of the …, 2021 - journals.lww.com
Despite evidence of multiorgan tropism of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in patients with coronavirus disease 2019 (COVID-19), direct viral kidney …