Pediatric acute myeloid leukemia (AML) represents 15%–20% of all pediatric acute
leukemias. Survival rates have increased over the past few decades to~ 70%, due to …

Acute myeloid leukemia (AML) is a group of hematological diseases, phenotypic and
genetically heterogeneous, characterized by abnormal accumulation of blast cells in the …

The protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays
a critical role in acute leukemias with translocations of the MLL1 gene or with mutations in …

Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute
leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is …

Type II topoisomerases are essential enzymes that modulate DNA under‐and overwinding,
knotting, and tangling. Beyond their critical physiological functions, these enzymes are the …

Acute lymphoblastic leukaemia (ALL) occurs at all ages but is the most common cancer of
childhood. The current treatment of paediatric ALL is highly successful with up to 90 …

2015 BMA Medical Book Awards Highly Commended in Oncology Category! The Molecular
Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle …

Breast cancer develops in the mammary glands during mammalian adulthood and is
considered the second most common type of human carcinoma and the most incident and …

From the bestselling author, Barbara J. Bain, the new edition of this practical reference on
the principles of leukaemia diagnosis and classification has been fully updated, and …

A number of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein
(MLL) N terminus to a variety of fusion partners that have been reported to reside in one or …