In mammals, secretin is a 27-amino acid peptide that was first studied in 1902 by Bayliss
and Starling from the extracts of the jejunal mucosa for its ability to stimulate pancreatic …

Secretin is secreted by S cells in the small intestine and affects the function of a number of
organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several …

Regional differences along the epididymis are essential for the establishment of the luminal
environment required for sperm maturation. In the current study, 19 morphologically distinct …

Aquaporin 2 (AQP2) is responsible for regulating the concentration of urine in the collecting
tubules of the kidney under the control of vasopressin (Vp). Studies using Vp-deficient …

Hypothalamic magnocellular neurons express either one of the neurohypophysial
hormones, vasopressin or oxytocin, along with different neuropeptides or neuromodulators …

The epithelia lining the epididymides of many species consists of several cell types. We
have provided evidence that the basal cells are essential to the integrated functions of the …

The epididymis establishes a congenial environment for sperm maturation and protection. Its
fluid is acidic, and the calcium concentration is low and declines along the length of the …

Secretin (Sct), a classical gut hormone, is now known to play pleiotropic functions in the
body including osmoregulation, digestion, and feeding control. As Sct has long been …

Secretin holds a unique place in the history of endocrinology and gastrointestinal
physiology, as it is the first peptide designated as a hormone. During the last century since …

The discovery of secretin initiated the field of endocrinology. Over the past century, multiple
gastrointestinal functions of secretin have been extensively studied, and it was discovered …