The current COVID-19 pandemic began in December 2019 in Wuhan (China) and rapidly
extended to become a global sanitary and economic emergency. Its etiological agent is the …

Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Immunosenescence is a series of age-related changes that affect the immune system and,
with time, lead to increased vulnerability to infectious diseases. This Review addresses …

The immune system plays a central role in tissue repair and regeneration. Indeed, the
immune response to tissue injury is crucial in determining the speed and the outcome of the …

Objective As aging progresses, clinical characteristics of elderly patients in the emergency
department (ED) vary by age. We aimed to study differences among elderly patients in the …

Normal repair of skeletal muscle requires local expansion of a special population of Foxp3+
CD4+ regulatory T (Treg) cells. Such cells failed to accumulate in acutely injured muscle of …

Older people are particularly susceptible to infectious and neoplastic diseases of the lung
and it is unclear how lifelong exposure to environmental pollutants affects respiratory …

Age-associated changes in CD4 T-cell functionality have been linked to chronic
inflammation and decreased immunity. However, a detailed characterization of CD4 T cell …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …