The immune systems of post-pubescent males and females differ significantly with profound
consequences to health and disease. In many cases, sex-specific differences in the immune …

Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and
contribute to neurodegenerative pathology. Although microglia have been the focus of work …

In studies of immune aging, naive T cells frequently take center stage. Describing the
complexity of the human naive T cell repertoire remains a daunting task; however, emerging …

A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of
pathogens, and TCR repertoire size is believed to decline with age. However, the precise …

Background Older age and chronic disease are important risk factors for developing severe
COVID-19. At population level, vaccine-induced immunity substantially reduces the risk of …

The efficacy of the adaptive immune response declines markedly with age, but the cell-
intrinsic mechanisms driving immune aging in humans remain poorly understood. Immune …

Ageing, like obesity, is often associated with alterations in metabolic and inflammatory
processes resulting in morbidity from diseases characterised by poor metabolic control …

As a hallmark of immunological aging, low-grade, chronic inflammation with accumulation of
effector memory T cells contributes to increased susceptibility to many aging-related …

Although advances in preventive medicine have greatly improved prognosis, cardiovascular
disease (CVD) remains the leading cause of death worldwide. This clearly indicates that …

Epidemiological studies have principally relied on measurements of telomere length (TL) in
leucocytes, which reflects TL in other somatic cells. Leucocyte TL (LTL) displays vast …