The aged microenvironment impairs BCL6 and CD40L induction in CD4+ T follicular helper cell differentiation
JS Fisher, I Adán‐Barrientos, NR Kumar… - Aging …, 2024 - Wiley Online Library
Weakened germinal center responses by the aged immune system result in diminished
immunity against pathogens and reduced efficacy of vaccines. Prolonged contacts between …
immunity against pathogens and reduced efficacy of vaccines. Prolonged contacts between …
[HTML][HTML] Leukocyte telomere length, T cell composition and DNA methylation age
Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with
chronological age. One measure of DNA methylation age-the extrinsic epigenetic age …
chronological age. One measure of DNA methylation age-the extrinsic epigenetic age …
Aging-associated immunosenescence via alterations in splenic immune cell populations in rat
Aim Immunosenescence is the decline of the host immune system due to aging, resulting in
various complications. The splenic lymphoid nodule is the pivotal compartment involved in …
various complications. The splenic lymphoid nodule is the pivotal compartment involved in …
Pancreas transplantation in older patients is safe, but patient selection is paramount
JR Scalea, RR Redfield III, E Arpali… - Transplant …, 2016 - Wiley Online Library
Pancreas transplant outcomes have progressively improved. Despite this, some centers
have continued to employ historical age limits for pancreas transplant candidates. We …
have continued to employ historical age limits for pancreas transplant candidates. We …
Depletion of preexisting B‐cell lymphoma 2‐expressing senescent cells before vaccination impacts antigen‐specific antitumor immune responses in old mice
O Cobanoglu, L Delval, D Ferrari, L Deruyter… - Aging cell, 2023 - Wiley Online Library
The age‐related decline in immunity reduces the effectiveness of vaccines in older adults.
Immunosenescence is associated with chronic, low‐grade inflammation, and the …
Immunosenescence is associated with chronic, low‐grade inflammation, and the …
Central tolerance is impaired in the middle‐aged thymic environment
One of the earliest hallmarks of immune aging is thymus involution, which not only reduces
the number of newly generated and exported T cells, but also alters the composition and …
the number of newly generated and exported T cells, but also alters the composition and …
Aging is accompanied by T‐cell stiffening and reduced interstitial migration through dysfunctional nuclear organization
B González‐Bermúdez, H Kobayashi… - …, 2022 - Wiley Online Library
Age‐associated changes in T‐cell function play a central role in immunosenescence. The
role of aging in the decreased T‐cell repertoire, primarily because of thymic involution, has …
role of aging in the decreased T‐cell repertoire, primarily because of thymic involution, has …
Conventional treatment for multiple myeloma drives premature aging phenotypes and metabolic dysfunction in T cells
RE Cooke, KM Quinn, H Quach, S Harrison… - Frontiers in …, 2020 - frontiersin.org
New diagnoses of multiple myeloma (MM) tend to occur after the age of 60, by which time
thymic output is severely reduced. As a consequence, lymphocyte recovery after …
thymic output is severely reduced. As a consequence, lymphocyte recovery after …
Immune response to COVID-19 in older adults
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third highly
pathogenic coronavirus to emerge in the human population in last two decades. SARS-CoV …
pathogenic coronavirus to emerge in the human population in last two decades. SARS-CoV …
Age-related decline of de novo T cell responsiveness as a cause of COVID-19 severity
To the Editor, So far, little attention has been paid to the link between immunosenescence
and the dramatic mortality rate of coronavirus disease 2019 (COVID-19) in older age groups …
and the dramatic mortality rate of coronavirus disease 2019 (COVID-19) in older age groups …