Construction of single-cell cross-species chromatin accessibility landscapes with combinatorial-hybridization-based ATAC-seq

G Zhang, Y Fu, L Yang, F Ye, P Zhang, S Zhang, L Ma… - Developmental Cell, 2024 - cell.com
Despite recent advances in single-cell genomics, the lack of maps for single-cell candidate
cis-regulatory elements (cCREs) in non-mammal species has limited our exploration of …

[PDF][PDF] JMnorm: a novel joint multi-feature normalization method for integrative and comparative epigenomics

G Xiang, Y Guo, D Bumcrot, A Sigova - Nucleic Acids Research, 2024 - academic.oup.com
Combinatorial patterns of epigenetic features reflect transcriptional states and functions of
genomic regions. While many epigenetic features have correlated relationships, most …

Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors

K Karatepe, B Mafra de Faria, J Zhang, X Chen, H Pinto… - bioRxiv, 2024 - biorxiv.org
Myeloid-biased differentiation of multipotent hematopoietic stem and progenitor cells
(HSPCs) occurs with aging or exhaustion. The molecular mechanism (s) responsible for this …