Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms

R Butowt, K Bilinska, CS von Bartheld - Trends in Neurosciences, 2023 - cell.com
The mechanisms of olfactory dysfunction in COVID-19 are still unclear. In this review, we
examine potential mechanisms that may explain why the sense of smell is lost or altered …

Mechanisms of SARS-CoV-2-associated anosmia

T Tsukahara, DH Brann, SR Datta - Physiological Reviews, 2023 - journals.physiology.org
Anosmia, the loss of the sense of smell, is one of the main neurological manifestations of
COVID-19. Although the SARS-CoV-2 virus targets the nasal olfactory epithelium, current …

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

GD de Melo, V Perraud, F Alvarez… - Nature …, 2023 - nature.com
Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the
emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has …

COVID‐19 induces neuroinflammation and suppresses peroxisomes in the brain

A Roczkowsky, D Limonta, JP Fernandes… - Annals of …, 2023 - Wiley Online Library
Objective Peroxisome injury occurs in the central nervous system (CNS) during multiple
virus infections that result in neurological disabilities. We investigated host neuroimmune …

Challenges and opportunities in long COVID research

RE Hamlin, CA Blish - Immunity, 2024 - cell.com
Long COVID (LC) is a condition in which patients do not fully recover from the initial SARS-
CoV-2 infection but rather have persistent or new symptoms for months to years following …

Effects of nasal inflammation on the olfactory bulb

BJ LaFever, F Imamura - Journal of neuroinflammation, 2022 - Springer
Sinonasal diseases, such as rhinosinusitis, affect up to 12% of individuals each year which
constitutes these diseases as some of the most common medical conditions in the world …

Mechanism and treatment of olfactory dysfunction caused by coronavirus disease 2019

B Hu, M Gong, Y Xiang, S Qu, H Zhu, D Ye - Journal of Translational …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the start of the …

The original strain of SARS-CoV-2, the Delta variant, and the Omicron variant infect microglia efficiently, in contrast to their inability to infect neurons: Analysis using 2D …

Y Kase, I Sonn, M Goto, R Murakami, T Sato… - Experimental …, 2023 - Elsevier
COVID-19 causes neurological damage, systemic inflammation, and immune cell
abnormalities. COVID-19-induced neurological impairment may be caused by severe acute …

Potential convergence of olfactory dysfunction in Parkinson's disease and COVID-19: The role of neuroinflammation

H Li, J Qian, Y Wang, J Wang, X Mi, L Qu… - Ageing Research …, 2024 - Elsevier
Parkinson's disease (PD) is a prevalent neurodegenerative disorder that affects 7-10 million
individuals worldwide. A common early symptom of PD is olfactory dysfunction (OD), and …

Mechanisms of long COVID: An updated review

Y Liu, X Gu, H Li, H Zhang, J Xu - Chinese Medical Journal …, 2023 - mednexus.org
The coronavirus disease 2019 (COVID-19) pandemic has been ongoing for more than 3
years, with an enormous impact on global health and economies. In some patients …