Epidemiology, clinical presentation, pathophysiology, and management of long COVID: an update

S Su, Y Zhao, N Zeng, X Liu, Y Zheng, J Sun… - Molecular …, 2023 - nature.com
The increasing number of coronavirus disease 2019 (COVID-19) infections have highlighted
the long-term consequences of severe acute respiratory syndrome coronavirus 2 (SARS …

[HTML][HTML] Persistent SARS-CoV-2 infection, EBV, HHV-6 and other factors may contribute to inflammation and autoimmunity in long COVID

A Vojdani, E Vojdani, E Saidara, M Maes - Viruses, 2023 - mdpi.com
A novel syndrome called long-haul COVID or long COVID is increasingly recognized in a
significant percentage of individuals within a few months after infection with SARS-CoV-2 …

[HTML][HTML] Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof …

HK Al-Hakeim, HT Al-Rubaye, DS Al-Hadrawi… - Molecular …, 2023 - nature.com
The immune-inflammatory response during the acute phase of COVID-19, as assessed
using peak body temperature (PBT) and peripheral oxygen saturation (SpO2), predicts the …

Adverse childhood experiences and reoccurrence of illness impact the gut microbiome, which affects suicidal behaviours and the phenome of major depression …

M Maes, A Vasupanrajit, K Jirakran… - Acta …, 2023 - cambridge.org
The first publication demonstrating that major depressive disorder (MDD) is associated with
alterations in the gut microbiota appeared in 2008 (Maes et al., 2008). The purpose of the …

[HTML][HTML] Lowered quality of life in long COVID is predicted by affective symptoms, chronic fatigue syndrome, inflammation and neuroimmunotoxic pathways

M Maes, HT Al-Rubaye, AF Almulla… - International journal of …, 2022 - mdpi.com
The physio-affective phenome of Long COVID-19 is predicted by (a) immune-inflammatory
biomarkers of the acute infectious phase, including peak body temperature (PBT) and …

[HTML][HTML] Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in long COVID

HK Al-Hakeim, A Khairi Abed… - Frontiers in Molecular …, 2023 - frontiersin.org
Critical COVID-19 disease is accompanied by depletion of plasma tryptophan (TRY) and
increases in indoleamine-dioxygenase (IDO)-stimulated production of neuroactive …

[HTML][HTML] Increased insulin resistance due to Long COVID is associated with depressive symptoms and partly predicted by the inflammatory response during acute …

HK Al-Hakeim, HT Al-Rubaye, AS Jubran… - Brazilian Journal of …, 2023 - SciELO Brasil
Objective: Some months after the remission of acute COVID-19, some individuals show
depressive symptoms, which are predicted by increased peak body temperature (PBT) and …

Reactivation of herpesvirus type 6 and IgA/IgM-mediated responses to activin-A underpin long COVID, including affective symptoms and chronic fatigue syndrome

A Vojdani, AF Almulla, B Zhou, HK Al-Hakeim… - Acta …, 2024 - cambridge.org
Background: Persistent infection with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), reactivation of dormant viruses, and immune-oxidative responses are …

[HTML][HTML] Chronic fatigue, depression and anxiety symptoms in long COVID are strongly predicted by neuroimmune and neuro-oxidative pathways which are caused by …

HK Al-Hakeim, HT Al-Rubaye, AF Almulla… - Journal of Clinical …, 2023 - mdpi.com
Background: Long-term coronavirus disease 2019 (long COVID) is associated with physio-
somatic (chronic fatigue syndrome and somatic symptoms) and affective (depression and …

[HTML][HTML] Chronic fatigue and affective symptoms in acute and long COVID are attributable to immune‐inflammatory pathways

AF Almulla, HK Al‐Hakeim, M Maes - Psychiatry and Clinical …, 2023 - ncbi.nlm.nih.gov
This letter to the editor aims to summarize our novel findings, which show the important
biological pathways underpinning fatigue, depression, and anxiety symptoms in patients …