[HTML][HTML] Strategies for targeting senescent cells in human disease
Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …
The central role of DNA damage in the ageing process
B Schumacher, J Pothof, J Vijg, JHJ Hoeijmakers - Nature, 2021 - nature.com
Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …
[HTML][HTML] Immune ageing at single-cell resolution
Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
[HTML][HTML] Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
[HTML][HTML] Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
R Kumari, P Jat - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
Cellular senescence is immunogenic and promotes antitumor immunity
I Marin, O Boix, A Garcia-Garijo, I Sirois, A Caballe… - Cancer discovery, 2023 - AACR
Cellular senescence is a stress response that activates innate immune cells, but little is
known about its interplay with the adaptive immune system. Here, we show that senescent …
known about its interplay with the adaptive immune system. Here, we show that senescent …
Senescence and the SASP: many therapeutic avenues
J Birch, J Gil - Genes & development, 2020 - genesdev.cshlp.org
Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …
triggers profound phenotypic changes such as the production of a bioactive secretome …
[HTML][HTML] Biological aging processes underlying cognitive decline and neurodegenerative disease
MM Gonzales, VR Garbarino, E Pollet… - The Journal of …, 2022 - Am Soc Clin Investig
Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …
disability and mortality in later life. As with many chronic conditions, aging is the single most …
The role of retrotransposable elements in ageing and age-associated diseases
The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …
the activity of transposable elements (transposons). Transposons are mobile genetic …
Senolytics reduce coronavirus-related mortality in old mice
INTRODUCTION The COVID-19 pandemic revealed enhanced vulnerability of the elderly
and chronically ill to adverse outcomes upon severe acute respiratory syndrome coronavirus …
and chronically ill to adverse outcomes upon severe acute respiratory syndrome coronavirus …