[HTML][HTML] Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis
T Ko, S Nomura, S Yamada, K Fujita, T Fujita… - Nature …, 2022 - nature.com
Tissue fibrosis and organ dysfunction are hallmarks of age-related diseases including heart
failure, but it remains elusive whether there is a common pathway to induce both events …
failure, but it remains elusive whether there is a common pathway to induce both events …
[HTML][HTML] Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease
The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …
[HTML][HTML] Algorithmic assessment of cellular senescence in experimental and clinical specimens
The development of genetic tools allowed for the validation of the pro-aging and pro-disease
functions of senescent cells in vivo. These discoveries prompted the development of …
functions of senescent cells in vivo. These discoveries prompted the development of …
[HTML][HTML] Connecting aging biology and inflammation in the omics era
KA Walker, N Basisty, DM Wilson… - The Journal of Clinical …, 2022 - Am Soc Clin Investig
Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …
architecture that triggers a proinflammatory state in blood and solid tissues, termed …
Inflammation and DNA damage: cause, effect or both
Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
[HTML][HTML] Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma
R Salam, A Saliou, F Bielle, M Bertrand… - Nature …, 2023 - nature.com
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it
remains refractory to systemic therapy. Elimination of senescent cells has emerged as a …
remains refractory to systemic therapy. Elimination of senescent cells has emerged as a …
[HTML][HTML] The role of antioxidants in the interplay between oxidative stress and senescence
Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro‐
inflammatory phenotype, thought to contribute to aging and age‐related diseases …
inflammatory phenotype, thought to contribute to aging and age‐related diseases …
[HTML][HTML] Therapy-induced senescence: an “old” friend becomes the enemy
T Saleh, S Bloukh, VJ Carpenter, E Alwohoush… - Cancers, 2020 - mdpi.com
For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …
[HTML][HTML] Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton
Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …