[HTML][HTML] Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain
RK Shahidehpour, RE Higdon, NG Crawford… - Neurobiology of …, 2021 - Elsevier
Loss of physiological microglial function may increase the propagation of
neurodegenerative diseases. Cellular senescence is a hallmark of aging; thus, we …
neurodegenerative diseases. Cellular senescence is a hallmark of aging; thus, we …
Salivary gland function, development, and regeneration
Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …
and overall health. Understanding both the unique structure and physiological function of …
Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition
Normal aging is accompanied by escalating systemic inflammation. Yet the potential impact
of immune homeostasis on neurogenesis and cognitive decline during brain aging have not …
of immune homeostasis on neurogenesis and cognitive decline during brain aging have not …
On the evolution of cellular senescence
The idea that senescent cells are causally involved in aging has gained strong support from
findings that the removal of such cells alleviates many age‐related diseases and extends …
findings that the removal of such cells alleviates many age‐related diseases and extends …
[HTML][HTML] Generation of a p16 reporter mouse and its use to characterize and target p16high cells in vivo
Cell senescence plays a key role in age-associated organ dysfunction, but the in vivo
pathogenesis is largely unclear. Here, we generated a p16-Cre ERT2-tdTomato mouse …
pathogenesis is largely unclear. Here, we generated a p16-Cre ERT2-tdTomato mouse …
Elimination of radiation-induced senescence in the brain tumor microenvironment attenuates glioblastoma recurrence
E Fletcher-Sananikone, S Kanji, N Tomimatsu… - Cancer research, 2021 - AACR
Glioblastomas (GBM) are routinely treated with ionizing radiation (IR) but inevitably recur
and develop therapy resistance. During treatment, the tissue surrounding tumors is also …
and develop therapy resistance. During treatment, the tissue surrounding tumors is also …
[HTML][HTML] Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration
M Wan, EF Gray-Gaillard, JH Elisseeff - Bone Research, 2021 - nature.com
Emerging insights into cellular senescence highlight the relevance of senescence in
musculoskeletal disorders, which represent the leading global cause of disability. Cellular …
musculoskeletal disorders, which represent the leading global cause of disability. Cellular …
[HTML][HTML] Hallmarks of aging and immunosenescence: connecting the dots
LP Rodrigues, VR Teixeira, T Alencar-Silva… - Cytokine & growth factor …, 2021 - Elsevier
Aging is a natural physiological process that features various and variable challenges,
associated with loss of homeostasis within the organism, often leading to negative …
associated with loss of homeostasis within the organism, often leading to negative …
Cellular senescence: from mechanisms to current biomarkers and senotherapies
V Lucas, C Cavadas, CA Aveleira - Pharmacological Reviews, 2023 - ASPET
An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …
related diseases. In the last few decades, several studies have provided evidence of the …
The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …