Mesenchymal stem cell-based therapy for cardiovascular disease: progress and challenges

L Bagno, KE Hatzistergos, W Balkan, JM Hare - Molecular Therapy, 2018 - cell.com
Administration of mesenchymal stem cells (MSCs) to diseased hearts improves cardiac
function and reduces scar. These effects occur via stimulation of endogenous repair …

Cyclodextrin-based host–guest supramolecular hydrogels for local drug delivery

G Fang, X Yang, S Chen, Q Wang, A Zhang… - Coordination Chemistry …, 2022 - Elsevier
Cyclodextrin (CD) is one of the most versatile substances produced by nature and can form
supramolecular hydrogels with polymers or small molecules based on non-covalent …

Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

J Zhao, X Li, J Hu, F Chen, S Qiao, X Sun… - Cardiovascular …, 2019 - academic.oup.com
Abstract Aims Mesenchymal stromal cells (MSCs) gradually become attractive candidates
for cardiac inflammation modulation, yet understanding of the mechanism remains elusive …

Randomized comparison of allogeneic versus autologous mesenchymal stem cells for nonischemic dilated cardiomyopathy: POSEIDON-DCM trial

JM Hare, DL DiFede, AC Rieger, V Florea… - Journal of the American …, 2017 - jacc.org
Background: Although human mesenchymal stem cells (hMSCs) have been tested in
ischemic cardiomyopathy, few studies exist in chronic nonischemic dilated cardiomyopathy …

Dilated cardiomyopathy and chronic cardiac inflammation: Pathogenesis, diagnosis and therapy

D Harding, MHA Chong, N Lahoti… - Journal of internal …, 2023 - Wiley Online Library
Dilated cardiomyopathy (DCM) is typically defined by left ventricular dilation and systolic
dysfunction in the absence of a clear precipitant. Idiopathic disease is common; up to 50% of …

Chitosan/silk fibroin modified nanofibrous patches with mesenchymal stem cells prevent heart remodeling post-myocardial infarction in rats

J Chen, Y Zhan, Y Wang, D Han, B Tao, Z Luo, S Ma… - Acta biomaterialia, 2018 - Elsevier
Poor functional survival of the engrafted stem cells limits the therapeutic efficacy of stem-cell-
based therapy for myocardial infarction (MI). Cardiac patch-based system for cardiac repair …

Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway

Y Xiong, R Tang, J Xu, W Jiang, Z Gong… - Stem cell research & …, 2022 - Springer
Abstract Background Bone marrow cells (BMCs), especially mesenchymal stem cells
(MSCs), have shown attractive application prospects in acute myocardial infarction (AMI) …

Nanozyme-Integrated Thermoresponsive In Situ Forming Hydrogel Enhances Mesenchymal Stem Cell Viability and Paracrine Effect for Efficient Spinal Cord Repair

L Xu, J Mu, Z Ma, P Lin, F Xia, X Hu, J Wu… - … Applied Materials & …, 2023 - ACS Publications
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising strategy for the
treatment of spinal cord injury (SCI). However, the hostile microenvironment of SCI, which …

Mesenchymal stem cell therapy for acute respiratory distress syndrome: from basic to clinics

H Qin, A Zhao - Protein & cell, 2020 - academic.oup.com
The 2019 novel coronavirus disease (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has occurred in China and around the world. SARS …

Clinical studies of cell therapy in cardiovascular medicine: recent developments and future directions

MN Banerjee, R Bolli, JM Hare - Circulation research, 2018 - Am Heart Assoc
Given the rising prevalence of cardiovascular disease worldwide and the limited therapeutic
options for severe heart failure, novel technologies that harness the regenerative capacity of …