NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Local immune recognition of trophoblast in early human pregnancy: controversies and questions

A Moffett, N Shreeve - Nature Reviews Immunology, 2023 - nature.com
The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

[HTML][HTML] NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing

I Prager, C Liesche, H Van Ooijen, D Urlaub… - Journal of Experimental …, 2019 - rupress.org
NK cells eliminate virus-infected and tumor cells by releasing cytotoxic granules containing
granzyme B (GrzB) or by engaging death receptors that initiate caspase cascades. The …

Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression

A Shemesh, Y Su, DR Calabrese, D Chen… - Journal of Experimental …, 2022 - rupress.org
Human adaptive-like natural killer (NK) cells express low levels of FcεRIγ (FcRγ−/low) and
are reported to accumulate during COVID-19 infection; however, the mechanism underlying …

Natural killer cells as allogeneic effectors in adoptive cancer immunotherapy

KB Lupo, S Matosevic - Cancers, 2019 - mdpi.com
Natural killer (NK) cells are attractive within adoptive transfer settings in cancer
immunotherapy due to their potential for allogeneic use; their alloreactivity is enhanced …

Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing

SL Smith, PR Kennedy, KB Stacey… - Blood …, 2020 - ashpublications.org
Children with immune thrombocytopenia (ITP) rarely suffer from life-threatening bleeds (eg,
intracranial hemorrhage). In such settings, the combination of IV methylprednisolone (IVMP) …

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping

H Netskar, A Pfefferle, JP Goodridge, E Sohlberg… - Nature …, 2024 - nature.com
The functional diversity of natural killer (NK) cell repertoires stems from differentiation,
homeostatic, receptor–ligand interactions and adaptive-like responses to viral infections. In …

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

O Huhn, MA Ivarsson, L Gardner, M Hollinshead… - Nature …, 2020 - nature.com
During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding
maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass …

You have got a fast CAR: chimeric antigen receptor NK cells in cancer therapy

A Pfefferle, ND Huntington - Cancers, 2020 - mdpi.com
The clinical success stories of chimeric antigen receptor (CAR)-T cell therapy against B-cell
malignancies have contributed to immunotherapy being at the forefront of cancer therapy …

[HTML][HTML] Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myeloma

H Nahi, M Chrobok, S Meinke, C Gran, N Marquardt… - Cell Reports …, 2022 - cell.com
Few approaches have been made toward exploring autologous NK cells in settings of
cancer immunotherapy. Here, we demonstrate the feasibility of infusing multiple doses of ex …