Renin-angiotensin system in pathogenesis of atherosclerosis and treatment of CVD

AV Poznyak, D Bharadwaj, G Prasad… - International Journal of …, 2021 - mdpi.com
Atherosclerosis has complex pathogenesis, which involves at least three serious aspects:
inflammation, lipid metabolism alterations, and endothelial injury. There are no effective …

Adverse effects of psychosocial work factors on blood pressure: systematic review of studies on demand-control-support and effort-reward imbalance models

M Gilbert-Ouimet, X Trudel, C Brisson, A Milot… - Scandinavian journal of …, 2014 - JSTOR
Objectives A growing body of research has investigated the adverse effects of psychosocial
work factors on blood pressure (BP) elevation. There is now a clear need for an up-to-date …

A century old renin–angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology

P Balakumar, G Jagadeesh - Cellular signalling, 2014 - Elsevier
Ang II, the primary effector pleiotropic hormone of the renin–angiotensin system (RAS)
cascade, mediates physiological control of blood pressure and electrolyte balance through …

Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients

F Huang, J Guo, Z Zou, J Liu, B Cao, S Zhang… - Nature …, 2014 - nature.com
Abstract A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the
spring of 2013. This virus causes severe disease in humans, including acute and often lethal …

The renin–angiotensin system and its involvement in vascular disease

BS van Thiel, I van der Pluijm, L te Riet, J Essers… - European journal of …, 2015 - Elsevier
The renin–angiotensin system (RAS) plays a critical role in the pathogenesis of many types
of cardiovascular diseases including cardiomyopathy, valvular heart disease, aneurysms …

Current understanding of the pivotal role of mitochondrial dynamics in cardiovascular diseases and senescence

Y Uchikado, Y Ikeda, M Ohishi - Frontiers in cardiovascular medicine, 2022 - frontiersin.org
The heart is dependent on ATP production in mitochondria, which is closely associated with
cardiovascular disease because of the oxidative stress produced by mitochondria …

Vitamin D receptor signaling inhibits atherosclerosis in mice

FL Szeto, CA Reardon, D Yoon, Y Wang… - Molecular …, 2012 - academic.oup.com
Although vitamin D has been implicated in cardiovascular protection, few studies have
addressed the role of vitamin D receptor (VDR) in atherosclerosis. Here we investigate the …

The potential therapeutic use of renin–angiotensin system inhibitors in the treatment of inflammatory diseases

R Ranjbar, M Shafiee, AR Hesari… - Journal of cellular …, 2019 - Wiley Online Library
Inflammation is a normal part of the immune response to injury or infection but its
dysregulation promotes the development of inflammatory diseases, which cause …

Molecular mechanisms of diabetes and atherosclerosis: role of adiponectin

K Kishida, T Funahashi… - Endocrine, Metabolic & …, 2012 - ingentaconnect.com
Type 2 diabetes mellitus (T2DM) is a disease characterized by inadequate beta-cell
response due to progressive insulin resistance that typically accompanies physical inactivity …

Angiotensin-(1–7) counteracts angiotensin II-induced dysfunction in cerebral endothelial cells via modulating Nox2/ROS and PI3K/NO pathways

X Xiao, C Zhang, X Ma, H Miao, J Wang, L Liu… - Experimental cell …, 2015 - Elsevier
Angiotensin (Ang) II, the main effector of the renin–angiotensin system, has been implicated
in the pathogenesis of vascular diseases. Ang-(1–7) binds to the G protein-coupled Mas …