[HTML][HTML] Genetic and epigenetic factors determining NAFLD risk

W Jonas, A Schürmann - Molecular metabolism, 2021 - Elsevier
Background Hepatic steatosis is a common chronic liver disease that can progress into more
severe stages of NAFLD or promote the development of life-threatening secondary diseases …

An update in epigenetics in metabolic-associated fatty liver disease

JS Rodríguez-Sanabria, R Escutia-Gutiérrez… - Frontiers in …, 2022 - frontiersin.org
Metabolic-associated fatty liver disease (MAFLD) is characterized by hepatic steatosis
accompanied by one of three features: overweight or obesity, T2DM, or lean or normal …

MicroRNAs and circular RNAs in lipoprotein metabolism

P Fernández-Tussy, I Ruz-Maldonado… - Current atherosclerosis …, 2021 - Springer
Abstract Purpose of Review Non-coding RNAs (ncRNAs) including microRNAs (miRNAs)
and circular RNAs (circRNAs) are pivotal regulators of mRNA and protein expression that …

microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity

T Horie, T Nakao, Y Miyasaka, T Nishino… - Nature …, 2021 - nature.com
Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a
central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable …

MicroRNAs Regulate Function in Atherosclerosis and Clinical Implications

Z Li, Y Zhao, S Suguro, R Suguro - Oxidative Medicine and …, 2023 - Wiley Online Library
Background. Atherosclerosis is considered the most common cause of morbidity and
mortality worldwide. Athermanous plaque formation is pathognomonic of atherosclerosis …

MicroRNA regulation of cholesterol metabolism

KM Citrin, C Fernández‐Hernando… - Annals of the New York …, 2021 - Wiley Online Library
MicroRNAs are small noncoding RNAs that regulate gene expression at the
posttranscriptional level. Since many microRNAs have multiple mRNA targets, they are …

Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis

S Miyagawa, T Horie, T Nishino… - Life Science …, 2023 - life-science-alliance.org
Nonalcoholic steatohepatitis (NASH) can lead to cirrhosis and hepatocellular carcinoma in
their advanced stages; however, there are currently no approved therapies. Here, we show …

Per-and polyfluoroalkyl substances, polychlorinated biphenyls, organochlorine pesticides, and polybrominated diphenyl ethers and dysregulation of MicroRNA …

Y Li, BO Baumert, E Costello, JC Chen, S Rock… - Environmental …, 2023 - Elsevier
Abstract Background Persistent organic pollutants (POPs) are chemicals characterized by
their environmental persistence. Evidence suggests that exposure to POPs, which is …

miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches

NL Price, L Goedeke, Y Suárez… - EMBO Molecular …, 2021 - embopress.org
Abstract miRNAs have emerged as critical regulators of nearly all biologic processes and
important therapeutic targets for numerous diseases. However, despite the tremendous …

[HTML][HTML] Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis

L Longo, PH Rampelotto, E Filippi-Chiela… - World Journal of …, 2021 - ncbi.nlm.nih.gov
BACKGROUND Cardiovascular disease is the main cause of death in metabolic-associated
fatty liver disease, and gut microbiota dysbiosis is associated with both of them. AIM To …